Planta Medica, Table of Contents Planta Med 1994; 60(1): 37-40DOI: 10.1055/s-2006-959404 Paper © Georg Thieme Verlag Stuttgart · New York In Vitro Inhibition of Cyclooxygenase and 5-Lipoxygenase by Alkamides from Echinacea and Achillea SpeciesBarbara Müller-Jakic1 , Walter Breu1 , Andrea Pröbstle1 , Karl Redl1 , Harald Greger2 , Rudolf Bauer1 , 3 1Institut für Pharmazeutische Biologie der Universität München, Karlstraße 29, D-80333 München, Federal Republic of Germany 2Botanisches Institut der Universität Wien, Abteilung für Vergleichende Phytochemie, Rennweg 14, A-1030 Wien, Austria 3Institut für Pharmazeutische Biologie der Universität Düsseldorf, Universitätsstr. 1, D-40225 Düsseldorf, Federal Republic of Germany Recommend Article Abstract PDF Download Buy Article Abstract Polyunsaturated alkamides isolated from Achillea species, Echinacea angustifolia DC., Anacyclus pyrethrum (L.) Link, and Aaronsohnia pubescens (Desf.) Bremer & Humphries, (Compositae) were shown to possess inhibitory activity in in vitro cyclooxygenase (sheep seminal microsomes) and 5-lipoxygenase (porcine leukocytes) assays. Activity appeared to depend on the particular structure of the alkamides. Key words Achillea species - Echinacea angustifolia - Anacyclus pyrethrum - Aaronsohnia pubescens - Compositae - unsaturated alkamides - cyclooxygenase inhibition - 5-lipoxygenase inhibition PDF (371 kb)
