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Planta Med 1994; 60(3): 204-208
DOI: 10.1055/s-2006-959459
Paper

© Georg Thieme Verlag Stuttgart · New York

Potent Anti-Tumor Activity and Low Toxicity of Tubeimoside 1 Isolated from Bolbostemma paniculatum

Lijian Yu1 , Rundi Ma1 , 3 , Yongqing Wang2 , Hoyoku Nishino3
  • 1Department of Biochemistry, Shaanxi Provincial Academy of Traditional Chinese Medicine and Pharmacology, Xian 710003, People's Republic of China
  • 2Department of Pharmacy, Shaanxi Provincial Health School, Xian, People's Republic of China
  • 3Department of Biochemistry, Kyoto Prefectural University of Medicine, Kyoto, Japan
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1993

1993

Publikationsdatum:
04. Januar 2007 (online)

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Abstract

Bolbostemma paniculatum (Maxim.) Franquet (Cucurbitaceae) is a traditional Chinese medicinal plant (1), from which tubeimoside 1 was isolated. The antitumor activity and toxicity of tubeimoside 1 was investigated in vivo and in vitro. The results showed that tubeimoside 1 exerts potent anti-tumor activity with low toxicity. The compound inhibited DNA synthesis and induced phenotypic reverse transformation of tumor cells.

Key words

Bolbostemma paniculatum (Maxim.) Franquet - Cucurbitaceae - tubeimoside 1 - antitumor activity - toxicity