Twelve iridoid glycosides have been evaluated for their anti-inflammatory activity
on two models: the carrageenan-induced mouse paw edema and the TPA-induced mouse ear
edema. Loganic acid was the most active (44.4% edema inhibition) on the former test,
whereas the catalpol derivative mixture isolated from Scrophularia, aucubin, verbenalin, and loganin, showed the hightest activity (from 72.0 to 80.0%
edema inhibition) on the latter. The results allowed us to establish the relationship
between the structure and anti-inflammatory activity on the basis of the different
patterns of substitution, particularly hydroxylation, unsaturation, and acylation.
Iridoid glucosides -
in vivo anti-inflammatory activity - structure/activity relationship
