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Planta Med 1994; 60(3): 232-234
DOI: 10.1055/s-2006-959465
Paper

© Georg Thieme Verlag Stuttgart · New York

Structural Considerations on the Iridoids as Anti-Inflammatory Agents

María del Carmen Recio, Rosa María Giner, S. Máñez, J. L. Ríos
  • Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Avda. Vicent Andrés Estellés s/n, E-46100 Burjassot, València, Spain
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Publication History

1993

1993

Publication Date:
04 January 2007 (online)

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Abstract

Twelve iridoid glycosides have been evaluated for their anti-inflammatory activity on two models: the carrageenan-induced mouse paw edema and the TPA-induced mouse ear edema. Loganic acid was the most active (44.4% edema inhibition) on the former test, whereas the catalpol derivative mixture isolated from Scrophularia, aucubin, verbenalin, and loganin, showed the hightest activity (from 72.0 to 80.0% edema inhibition) on the latter. The results allowed us to establish the relationship between the structure and anti-inflammatory activity on the basis of the different patterns of substitution, particularly hydroxylation, unsaturation, and acylation.

Key words

Iridoid glucosides - in vivo anti-inflammatory activity - structure/activity relationship