Gastro-Protective Effects of Extracts of Petasites hybridus: The Role of Inhibition of Peptido-Leukotriene Synthesis

Kay Brune; Daniela Bickel; Bernhard A. Peskar

doi:10.1055/s-2006-959746

Planta Medica, Table of Contents

Planta Med 1993; 59(6): 494-496
DOI: 10.1055/s-2006-959746

Papers

Gastro-Protective Effects of Extracts of Petasites hybridus: The Role of Inhibition of Peptido-Leukotriene Synthesis

Kay Brune¹ , Daniela Bickel¹ , Bernhard A. Peskar²

¹Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen, Universitätsstr. 22, D-80225 Erlangen, Federal Republic of Germany
²Department of Pharmacology and Toxicology, University of Bochum, Universitätsstr. 150, D-44801 Bochum, Federal Republic of Germany

Abstract

PDF Download

Abstract

Extracts from Petasites hybridus are in therapeutic use for more than 2000 years. They have been claimed to improve gastrointestinal pain, lung-diseases such as asthma and cough, as well as spasms of the urogenital-tract. We have investigated these claims in animal models of gastro-intestinal ulcers and confirmed that alcoholic extracts of Petasites hybridus block the ethanol-induced gastric damage and reduce small intestinal ulcerations induced in rats by indomethacin. Searching for a possible mode of action, we found that ethanolic extracts of Petasites hybridus in hibit the peptido-leukotriene biosynthesis in mouse peritoneal macrophages but leave prostaglandin biosynthesis unimpaired. We conclude that the active principle could be useful in the treatment of gastrointestinal human diseases and that Petasites hybridus may contribute to the inhibition of calcium-dependent processes such as leukotriene biosynthesis.

Key words

Petasites hybridus - cytoprotection - ulcer - peptido-leukotrienes

PDF (319 kb)