Subalpinosid (S1), ein bisher unbekanntes Oleandrigeninglykosid und weitere Cardenolide aus Digitalis subalpina var. subalpina

J. J. Lichius; D. El Khyari; M. Wichtl

doi:10.1055/s-2006-960055

Planta Med 1991; 57(2): 159-161
DOI: 10.1055/s-2006-960055

Papers

Subalpinosid (S1), ein bisher unbekanntes Oleandrigeninglykosid und weitere Cardenolide aus Digitalis subalpina var. subalpina

Subalpinoside (S1), an Unknown Oleandrigenin Glycoside and Other Cardenol from Digitalis subalpina var. subalpina J. J. Lichius¹ , D. El Khyari² , M. Wichtl¹

¹Institut für Pharmazeutische Biologie der Philipps-Universität Marburg, D-3550 Marburg/L., Federal Republic of Germany
²Laboratoire de Biologie, Département de Biologie, Faculté des sciences, Université Mohammed V., Rabat, Maroc

Abstract

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Abstract

From the leaves of Digitalis subalpina Br.-Bl. var. subalpina an oleandrigenin glycoside was isolated as the main cardiotonic compound besides some known glycosides such as evatromonoside, lanatoside A and B, gitoroside, and others. The structure of this compound was elucidated by spectroscopic methods (¹H-, ¹³C-, 2D-NMR spectroscopy) as gluco-oleandrigenin digitoxoside. This is the first report of the occurrence of oleandrigenin derivatives in a Digitalis species.

Key words

Digitalis subalpina - cardiotonic activity - oleandrigenin derivatives - cardenolide glycosides - subalpinoside (S1)

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