6-Pentadecylsalicylic Acid; An Antithrombin Component Isolated from the Stem of Rhus semialata varroxburghii

Sheng-Chu Kuo; Che-Ming Teng; Lih-Gen Lee; Tai-Hui Chiu; Tian-Shung Wu; Shung-Chueh Huang; Jin-Bin Wu; Tiaur-Yarng Shieh; Ruey-Ju Chang; Teh-Chang Chou

doi:10.1055/s-2006-960083

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Planta Med 1991; 57(3): 247-249
DOI: 10.1055/s-2006-960083

Papers

6-Pentadecylsalicylic Acid; An Antithrombin Component Isolated from the Stem of Rhus semialata varroxburghii

Sheng-Chu Kuo¹ ^, ⁵ , Che-Ming Teng² ^, ⁵ , Lih-Gen Lee² , Tai-Hui Chiu¹ , Tian-Shung Wu³ , Shung-Chueh Huang¹ , Jin-Bin Wu¹ , Tiaur-Yarng Shieh¹ , Ruey-Ju Chang¹ , Teh-Chang Chou⁴

¹Graduate Institute of Pharmaceutical Chemistry, China Medical College, 91 Hsueh Shih Road, Taichung, Taiwan, Republic of China
²Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China
³Department of Chemistry, National Cheng-Kung University, Tainan, Taiwan, Republic of China
⁴Department of Chemistry, Tunghai University, Taichung, Taiwan, Republic of China
⁵National Research Institute of Chinese Medicine, Taipei, Taiwan, Republic of China

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Publikationsverlauf

1990

Publikationsdatum:
05. Januar 2007 (online)

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Abstract

Bioassay-directed fractionation of the n-hexane extract of the stem of Rhus semialata Murr. var. roxburghii DC (Anacardiaceae) has led to the isolation of 6-pentadecylsalicylic acid. It showed antithrombin activity at 50 µg/ml in the amidolytic method. It also prolonged the clotting time in a dose-dependent manner in the clotting assay of thrombin-fibrinogen interaction.

Key words

6-Pentadecylsalicylic acid - antithrombin - amidolytic method - clotting time - lanatebulic acid - Rhus semialata

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