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Planta Med 1991; 57(4): 352-356
DOI: 10.1055/s-2006-960116
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© Georg Thieme Verlag Stuttgart · New York

T-Cadinol: A Pharmacologically Active Constituent of Scented Myrrh: Introductory Pharmacological Characterization and High Field 1H- and 13C-NMR Data

Per Claeson1 , Rolf Andersson2 , Gunnar Samuelsson1
  • 1Department of Pharmacognosy, Biomedical Center, Uppsala University, Box 579, S-751 23 Uppsala, Sweden
  • 2Department of Chemistry, Swedish University of Agricultural Sciences, Box 7015, S-750 07 Uppsala, Sweden
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Publication History

1990

Publication Date:
05 January 2007 (online)

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Abstract

Fractionation of an ethyl acetate extract of scented myrrh (resin of Commiphora guidottii Chiov., Burseraceae), using the guinea pig ileum test to monitor pharmacological activity, resulted in isolation of the sesquiterpene (+)-T-cadinol. High field NMR spectroscopy yielded new detailed 1H- and 13C-NMR data for the compound. T-cadinol was shown to have a concentration-dependent smooth muscle relaxing effect on the isolated guinea pig ileum and a dose-dependent inhibitory effect on cholera toxin-induced intestinal hypersecretion in mice.

Key words

Scented myrrh - Commiphora guidottii - Burseraceae - T-cadinol - sesquiterpene - NMR - smooth muscle relaxing effect - intestine - cholera toxin - antidiarrhoeal effect