In vitro Anti-Helicobacter pylori Activity of Some Flavonoids and Their Metabolites

Eun-Ah Bae; Myung Joo Han; Dong-Hyun Kim

doi:10.1055/s-2006-960805

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Planta Med 1999; 65(5): 442-443
DOI: 10.1055/s-2006-960805

Letter

In vitro Anti-Helicobacter pylori Activity of Some Flavonoids and Their Metabolites

Eun-Ah Bae¹ , Myung Joo Han¹ , Dong-Hyun Kim²

¹Department of Food and Nutrition, Kyung-Hee University, Seoul, Korea
²College of Pharmacy, Kyung-Hee University, Seoul, Korea

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1998

1999

Publikationsdatum:
04. Januar 2007 (online)

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Abstract

The inhibitory effect of flavonoids and phenolic acids, which could be transformed from flavonoids by human intestinal microflora, on the growth of Helicobocter pylori (HP) was investigated. Ponciretin, hesperetin, naringenin and diosmetin were active against HP. Among them, ponciretin was the most potent and its MIC was 10-20 µg/ml. However, these active compounds against HP did nearly not inhibit the urease activity of HP.