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Planta Med 1999; 65(5): 448-449
DOI: 10.1055/s-2006-960808
Letter

© Georg Thieme Verlag Stuttgart · New York

Antimalarial Activity and Cytotoxicity of (-)-Roemrefidine Isolated from the Stem Bark of Sparattanthelium amazonum

V. Muñoz1 , M. Sauvain2 , P. Mollinedo1 , J. Callapa1 , I. Rojas1 , A. Gimenez3 , A. Valentin4 , M. Mallié4
  • 1Instituto Boliviano de Biologia de Altura, La Paz, Bolivia
  • 2Institut de Recherche pour le Développement, Paris, France
  • 3Instituto de Investigaciones Farmaco-Bioquímicas, Universidad Mayor de San Andrés, La Paz, Bolivia
  • 4Laboratoire d'lmmunologie et Parasitologie, UFR Sciences Pharmaceutiques, Montpellier, France
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1998

1999

Publikationsdatum:
04. Januar 2007 (online)

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Abstract

(-)-Roemrefidine, an aporphine alkaloid isolated from Sparattanthelium amazonum Martius (Hernandiaceae) a vine from Bolivia, has been found to be active against both resistant and sensitive strains of Plasmodium falciparum in vitro and against P. berghei in mice. The compound demonstrated no cytotoxic activity against three cell lines (KB, HEp-2 and HeLa).