Abstract
The activity-guided fractionation of the extract of the root of Salvia miltiorrhiza B. (Labiatae, Tanshen), led to the isolation of four active components responsible
for the anti-allergic activity in vitro. Among them, 15,16-dihydrotanshinone-I and cryptotanshinone demonstrated significant
inhibition of the release of β-hexosaminidase from cultured RBL-2H3 cells in a dose-dependent
manner; the IC50 values were calculated as 16 and 36 µM, respectively.