Planta Med 1999; 65(8): 757-758
DOI: 10.1055/s-2006-960859

© Georg Thieme Verlag Stuttgart · New York

Antiplasmodial Activity of Knipholone and Related Natural Phenylanthraquinones

Gerhard Bringmann1 , Dirk Menche1 , Merhatibeb Bezabih2 , Berhanu M. Abegaz2 , Ronald Kaminsky3
  • 1Institut für Organische Chemie der Universität, Würzburg, Germany
  • 2Department of Chemistry, University of Botswana, Gaborone, Botswana
  • 3Schweizerisches Tropeninstitut, Basel, Switzerland
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Publication History



Publication Date:
04 January 2007 (online)


The phenylanthraquinone knipholone (1) and three of its natural derivatives as well as seven structurally related but simplified compounds have been examined for their antiplasmodial activity against asexual erythrocytic stages of two strains of Plasmodium falciparum in vitro (K1/chloroquine-resistant and NF 54/chloroquine-sensitive). All the phenylanthraquinones showed considerable activity with only little cytotoxicity, while their anthraquinone and phenyl moieties were completely inactive. Knipholone (1) and its natural derivatives can therefore be considered as a new group of potential antimalarials.