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Planta Med 1990; 56(5): 439-443
DOI: 10.1055/s-2006-961006
Paper

© Georg Thieme Verlag Stuttgart · New York

Antiviral Activity of an Extract of Cordia salicifolia on Herpes Simplex Virus Type 1

Kyoko Hayashi1 , Toshimitsu Hayashi2 , Naokata Morita2 , Seihachiro Niwayama1
  • 1Department of Virology, Toyama Medical and Pharmaceutical University, Sugitani, Toyama 930-01, Japan
  • 2Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Sugitani, Toyama 930-01, Japan
Further Information

Publication History

1989

Publication Date:
05 January 2007 (online)

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Abstract

A partially purified extract (COL 1-6) from whole plant of Cordia salicifolia showed an inhibitory effect on herpes simplex virus type 1 (HSV-1). The activity of COL 1-6 on different steps of HSV-1 replication in HeLa cells was investigated. Under single-cycle replication conditions, COL 1-6 exerted a greater than 99.9% inhibition in virus yield when added to the cells 3 h or 1.5 h before infection, and even when added 8 h after infection the extract still caused a greater than 99% inhibition. The extract has been shown to have a direct virucidal activity. And also, analysis of early events following infection showed that COL 1-6 affected viral penetration in HeLa cells but did not interfere with adsorption to the cells.

Key words

Cordia salicifolia - herpes simplex virus type 1 - antiviral activity - HeLa cells - virus replication