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Planta Med 1990; 56(5): 444-445
DOI: 10.1055/s-2006-961007
Paper

© Georg Thieme Verlag Stuttgart · New York

Molluscicidal Properties of Constituents from the Liverwort Ricciocarpos natans and of Synthetic Lunularic Acid Derivatives

G. Wurzel1 , H. Becker1 , Th. Eicher2 , K. Tiefensee2
  • 1Fachbereich 14.3 Pharmakognosie und Analytische Phytochemie, Universität des Saarlandes, D-6600 Saarbrücken 11, Federal Republic of Germany
  • 2Fachbereich 13 Organische Chemie, Universität des Saarlandes, D-6600 Saarbrücken 11, Federal Republic of Germany
Further Information

Publication History

1989

Publication Date:
05 January 2007 (online)

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Abstract

Five new sesquiterpenoids, three mono-cyclofarnesane, and two cuparane derivatives, isolated from the liverwort Ricciocarpos natans (L.) Corda have been tested against Biomphalaria glabrata, one of the snail vectors of schistosomiasis (bilharzia). Molluscicidal activity is exhibited by four of the sesquiterpenoids with an LC100 of 11 ppm of the most toxic compound. Lunularic acid, a common growth inhibitor of liverworts, and five of its synthetic derivatives have also been tested, and two derivatives were found to be highly active.

Key words

Liverwort - lunularic acid derivatives - molluscicidal activity - Ricciocarpos natans - schistosomiasis - sesquiterpenoids