Planta Med 1992; 58(4): 317-320
DOI: 10.1055/s-2006-961475

© Georg Thieme Verlag Stuttgart · New York

Antisickling Activity of Hydroxybenzoic Acids in Cajanus cajan

F. O.B. Akojie1 , L. W.-M. Fung2
  • 1Department of Biochemistry, University of Benin, P.M.B. 1154, Benin City, Nigeria
  • 2Department of Chemistry, Loyola University of Chicago, 6525 N. Sheridan Road, Chicago, Illinois 60626, U.S.A.
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Publication History


Publication Date:
05 January 2007 (online)


The amounts of phenylalanine and hydroxybenzoic acid in a Cajanus cajan methanolic extract were estimated. Results showed that the amount of phenylalanine and hydroxybenzoic acid per gram weight of bean was 4.92 mg ± 0.13 mg and 21.0 mg ± 3.0 µg, respectively. Sickling inhibition was observed to be efficient with the extract which contains a mixture of phenylalanine (0.69 mg/ml) and p-hydroxybenzoic acid (10.5 µg/ml), equivalent to those found in bean extract. The additive antisickling effect of both compounds can be therapeutically exploited for the treatment of sickle cell anemia.