Anti-Inflammatory Activity of Gallic Acid

B. H. Kroes; A. J. J. van den Berg; H. C. Quarles van Ufford; H. van Dijk; R. P. Labadie

doi:10.1055/s-2006-961535

Planta Medica, Table of Contents

Planta Med 1992; 58(6): 499-504
DOI: 10.1055/s-2006-961535

Papers

Anti-Inflammatory Activity of Gallic Acid

B. H. Kroes¹ , A. J. J. van den Berg¹ , H. C. Quarles van Ufford¹ , H. van Dijk² , R. P. Labadie¹

¹Research Centre for Natural Products and Phytopharmaceuticals, Faculty of Pharmacy, University of Utrecht, Sorbonnelaan 16, 3508 TB Utrecht, The Netherlands
²Section of Experimental Immunology, Laboratory of Microbiology, Medical Faculty, University of Utrecht, The Netherlands

Abstract

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Abstract

Gallic acid was found to possess anti-inflammatory activity towards zymosan-induced acute food pad swelling in mice. In vitro studies on the mode of action of gallic acid revealed that this compound interferes with the functioning of polymorphonuclear leukocytes (PMNs). Scavenging of superoxide anions, inhibition of myeloperoxidase release and activity as well as a possible interference with the assembly of active NADPH-oxidase may account for the inhibition of inflammatory process by gallic acid. Structure-activity relationship analysis showed that the o-dihydroxy group of gallic acid is important for the inhibitory activity in vitro.

Key words

Gallic acid - anti-inflammatory activity - granulocytes - immunomodulation - chemiluminescence.

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