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Planta Med 1989; 55(2): 127-132
DOI: 10.1055/s-2006-961904
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© Georg Thieme Verlag Stuttgart · New York

Choleretic and Hepatoprotective Properties of Eupatorium cannabinum in the Rat

Annette Lexa1 , Jacques Fleurentin1 , Paul R. Lehr2 , François Mortier3 , Marc Pruvost4 , Jean-Marie Pelt1 , 5
  • 1Laboratoire de Pharmacognosie, Centre des Sciences de l'Environnement, Université de Metz, 1, rue des Récollets, F-57000 Metz, France
  • 2Laboratoire de Neurotoxicologie, Centre des Sciences de l'Environnement, Université de Metz, 1, rue des Récollets, F-57000 Metz, France
  • 3Laboratoire de Pharmacognosie, Faculté de Pharmacie, Université de Nancy, 5, rue Albert Lebrun, F-54000 Nancy, France
  • 4Sanofi Recherche, 195, route d'Espagne, F-31035 Toulouse, France
  • 5Institut Européen d'Ecologie, 1, rue des Récollets, F-57000 Metz, France
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Publication History

1988

Publication Date:
24 January 2007 (online)

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Abstract

According to our results, the traditional therapeutic indications of Eupatorium cannabinum L., choleretic and hepatoprotective effects, have been widely demonstrated. An aqueous extract induces hypercholeresis in the rat, the site of bile formation is canalicular in origin and both bile acid-dependant and bile acid-independant flows could be stimulated; the extract possesses anti-necrotic properties against carbon tetrachloride-induced hepatotoxicity, reducing widely the plasma GPT level in pretreated rats.