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Planta Med 1988; 54(3): 191-192
DOI: 10.1055/s-2006-962400
Papers

© Georg Thieme Verlag Stuttgart · New York

Non-Amphetaminic Central Stimulation by Alkaloids from the Ibogane and Vobasine Series

Maryse Bert1 , René Marcy2 , Marie-Anne Quermonne2 , Michel Cotelle2 , Michel Koch3
  • 1Department of Pharmacognosy, UER des Sciences maceutiques, 1 rue Vaubenard, F-14000 Caen, France.
  • 2Department of Pharmacology, UER des Sciences Pharmaceutiques, 1 rue Vaubenard, F-14000 Caen, France.
  • 3Department of Pharmacognosy, Faculté des Sciences Pharmaceutiques et Biologiques, 4 Avenue de l'Observatoire, F-75006 Paris, France.
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Publikationsverlauf

1987

Publikationsdatum:
24. Januar 2007 (online)

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Abstract

Ibogane alkaloids were shown to have a very high arousal activity. Similarly, a stimulating CNS activity was demonstrated for vobasine alkaloids. The influence of certain substituents was evidenced: a methoxy substituent increases the activity, while it is lowered by a methoxycarbonyl substituent.