Non-Amphetaminic Central Stimulation by Alkaloids from the Ibogane and Vobasine Series

Maryse Bert; René Marcy; Marie-Anne Quermonne; Michel Cotelle; Michel Koch

doi:10.1055/s-2006-962400

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Planta Med 1988; 54(3): 191-192
DOI: 10.1055/s-2006-962400

Papers

Non-Amphetaminic Central Stimulation by Alkaloids from the Ibogane and Vobasine Series

Maryse Bert¹ , René Marcy² , Marie-Anne Quermonne² , Michel Cotelle² , Michel Koch³

¹Department of Pharmacognosy, UER des Sciences maceutiques, 1 rue Vaubenard, F-14000 Caen, France.
²Department of Pharmacology, UER des Sciences Pharmaceutiques, 1 rue Vaubenard, F-14000 Caen, France.
³Department of Pharmacognosy, Faculté des Sciences Pharmaceutiques et Biologiques, 4 Avenue de l'Observatoire, F-75006 Paris, France.

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Publication History

1987

Publication Date:
24 January 2007 (online)

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Abstract

Ibogane alkaloids were shown to have a very high arousal activity. Similarly, a stimulating CNS activity was demonstrated for vobasine alkaloids. The influence of certain substituents was evidenced: a methoxy substituent increases the activity, while it is lowered by a methoxycarbonyl substituent.