Planta Med 1987; 53(1): 34-36
DOI: 10.1055/s-2006-962612
Full Papers

© Georg Thieme Verlag Stuttgart · New York

Antitumour Effects of Glycoalkaloids Isolated from Solanum sodomaeum

Bill E. Cham1 , Merv Gilliver2 , Linda Wilson3
  • 1Department of Medicine, University of Queensland, Clinical Sciences Building, Royal Brisbane Hospital, Queensland, 4029, Australia.
  • 2Department of Veterinary Pathology, University of Queensland, St. Lucia, Queensland, 4061, Australia.
  • 3Marist Brothers College, Fernberg Road, Rosalie, Queensland, 4064, Australia.
Further Information

Publication History

5 14 1986

Publication Date:
24 January 2007 (online)

Abstract

Glycoalkaloids extracted from Solanum sodomaeum L. show antineoplastic activity against Sarcoma 180 in mice. Approximately 33% of the total glycoalkaloid content consisted of the triglycoside solasonine and 33% of the triglycoside solamargine. The remainder was a mixture of mono- and diglycosides in which the aglycone was solasodine. Single dose studies of these glycoalkaloids with mice containing Sarcoma 180 indicated that the ED50 was 9 mg/kg, whereas the LD50 was 30 mg/kg resulting in a therapeutic index of 3.3. Single dosages of 8 mg/kg given on two consecutive days resulted in inhibition of tumour progression with greater than 40% survival. In contrast, the use of the same dosages given on three or four consecutive days resulted in greater than 90% survival.