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Planta Med 1987; 53(2): 124-127
DOI: 10.1055/s-2006-962652
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© Georg Thieme Verlag Stuttgart · New York

Effect of Extract from Rhei Rhizoma on Dietary Hyperazotemia in Rats

Takako Yokozawa1 , Shuji Miyakawa2 , Maomi Suzuki1 , Hikokichi Oura1 , Ko Kaneko2 , Itsuo Nishioka3
  • 1Department of Applied Biochemistry, Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Sugitani, Toyama 930-01, Japan.
  • 2Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo 060, Japan.
  • 3Faculty of Pharmaceutical Sciences, Kyushu University, Maidashi, Higashi-ku, Fukuoka 812, Japan.
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Publication History

1985

Publication Date:
24 January 2007 (online)

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Abstract

Although rats fed on a high protein diet of 70% casein showed hyperazotemia, administration of the extract from Rhei rhizoma showed decreases of blood urea nitrogen, ammonia nitrogen in the portal vein, urea concentration in hepatic tissue, Gln, Lys, Thr, Ala, Gly, Ser, Glu, Pro, Arg, Tyr, Cit, Asp, etc. in serum, while significant increases of Glu and Asp in hepatic tissue were observed. The mechanism of the blood urea nitrogen-decreasing activity of rhubarb extract is discussed on the basis of the present results.

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