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Planta Med 1987; 53(3): 280-284
DOI: 10.1055/s-2006-962706
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© Georg Thieme Verlag Stuttgart · New York

Effect of Sterol Inhibitors on the Incorporation of 14 C-Isopentenyl Pyrophosphate into Artemisinin by a Cell-Free System from Artemisia annua Tissue Cultures and Plants

G. Jose Kudakasseril1 , Luke Lam2 , E. John Staba2
  • 1Department of Biology, Kenyon College, Gambier, Ohio 43022, U.S.A.
  • 2Department of Medicinal Chemistry and Pharmacognosy, University of Minnesota, Minneapolis, Minnesota 55455, U.S.A.
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Publication History

1986

Publication Date:
24 January 2007 (online)

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Abstract

A cell-free system from Artemisia annua L. shoot cultures and plants (shoots and roots) which is capable of incorporating 14 C-isopentenyl pyrophosphate (14 C-IPP) into artemisinin has been developed. The sterol inhibitors miconazole, AMO 1618, CCC, and MER 29 increased both the incorporation of 14 C-IPP into artemisinin by cell-free extracts and the production of artemisinin in shoot cultures of Artemisia annua.

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