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Planta Med 1987; 53(5): 470-474
DOI: 10.1055/s-2006-962775
DOI: 10.1055/s-2006-962775
Full Papers
© Georg Thieme Verlag Stuttgart · New York
Stimulation of Indole Alkaloid Production in Cell Suspension Cultures of Catharanthus roseus by Abscisic Acid
Further Information
Publication History
1986
Publication Date:
24 January 2007 (online)
Abstract
When added to suspension cultures of Catharanthus roseus, abscisic acid (ABA) stimulated intracellular accumulation of the indole alkaloids catharanthine and ajmalicine in both flask and 30 litre fermenter-scale systems. The response varied, and depended upon the cell line, the concentration and source of the ABA, and the growth phase at which the cells were treated. Precise timing of ABA addition to cells in a 301 fermenter resulted in a catharanthine yield of 85.25 mg/l after 10 days of cultivation. We propose that ABA may be useful for increasing the yield and reducing the production time for commercially useful secondary plant metabolites.