Chemoselective O-Acylation of Aminoalcohols Catalyzed by a Zinc Cluster

doi:10.1055/s-2007-1072780

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Synfacts 2008(6): 0627-0627
DOI: 10.1055/s-2007-1072780

Metal-Mediated Synthesis

Chemoselective O-Acylation of Aminoalcohols Catalyzed by a Zinc Cluster

Contributor(s): Paul Knochel, Tobias Thaler
T. Ohshima*, T. Iwasaki, Y. Maegawa, A. Yoshiyama, K. Mashima*
Osaka University, Japan

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Publication History

Publication Date:
21 May 2008 (online)

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Significance

A highly O-selective Zn-cluster-catalyzed transesterification reaction was developed. A change from the usual azaphilic nature of Zn²⁺ ions to rather oxophilic Zn²⁺ takes place in the cluster. Selective O-acylation of various aminoalcohols without the use of protective groups was thus possible.