Abstract
Malignant schwannoma (malignant peripheral nerve sheath tumour, MPNST) is a rare high-grade
tumour arising from peripheral nerves. We report the case of a 3-year-old male who
presented with a non-tender lesion on the dorsum of his penis. The lesion was excised
and a formal circumcision performed. Histology of the lesion revealed a spindle cell
tumour. Immunohistochemistry showed the tumour cells to be strongly positive for S100
and Vimentin. A diagnosis of intermediate grade malignant peripheral nerve sheath
tumour was made. Malignant schwannoma is rare in children and is previously unreported
in the penis in the paediatric age group without evidence of neurofibromatosis.
Key words
penile - schwannoma - neurofibromatosis
References
- 1
Aloi F, Mödl G, Solaroli C.
[Malignant schwannoma of the glans penis].
Hautarzt.
1995;
46
656-659
- 2
Coffin C M, Dehner L P.
Peripheral neurogenic tumors of the soft tissues in children and adolescents: a clinicopathologic
study of 139 cases.
Pediatr Pathol.
1989;
9
387-407
- 3
Dehner L P, Smith B H.
Soft tissue tumors of the penis. A clinicopathologic study of 46 cases.
Cancer.
1970;
25
1431
- 4
Ducatman B S, Scheithauer B W, Piepgras D G, Reiman H M, Ilstrup D M.
Malignant peripheral nerve sheath tumors. A clinicopathologic study of 120 cases.
Cancer.
1986;
57
2006-2021
- 5
Ducatman B S, Scheithauer B W, Piepgras D G, Reiman H M.
Malignant peripheral nerve sheath tumors in childhood.
J Neurooncol.
1984;
2
241-248
- 6
Meis J M, Enzinger F M, Martz K L, Neal J A.
Malignant peripheral nerve sheath tumors (malignant schwannomas) in children.
Am J Surg Pathol.
1992;
16
694-707
- 7 Weiss S W, Goldblum J R. Enzinger and Weiss's Soft Tissue Tumours. 4th ed. St. Louis,
MO; Mosby Inc. 2001: 1209-1263
Professor Prem Puri
Director of Research
Children's Research Centre
Our Lady's Children's Hospital
Crumlin
Dublin 12
Ireland
Email: prem.puri@ucd.ie
