Abstract
A novel variation of the boronic acid Mannich (BAM) reaction is described, in which
α,α-dichloro- and α,α,ω-trichloroaldehydes, morpholine, and arylboronic acids are
used. During this one-pot reaction in refluxing toluene, 1-phenyl-1-morpholinoalkan-2-ones
form in moderate yields. The dichloromethylene group is formally converted into a
ketone functionality and as such acts as a masked carbonyl group.
Key words
boron - addition reactions - Mannich bases - Petasis reaction
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