Synthesis 2007(3): 348-350  
DOI: 10.1055/s-2007-965885
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York

Facile One-Step Synthesis of Mono-2-(p-Tolylsulfonyl)-β-cyclodextrin under Aqueous Conditions

Michael Strerath, Martin Meng, Stefan Kubik*
Technische Universität Kaiserslautern, Fachbereich Chemie - Organische Chemie, Erwin-Schrödinger-Strasse, 67663 Kaiserslautern, Germany
Fax: +49(631)2053921; e-Mail: kubik@chemie.uni-kl.de;
Further Information

Publication History

Received 21 September 2006
Publication Date:
12 January 2007 (online)

Abstract

A new and convenient method is presented for the synthesis of mono-2-(p-tolylsulfonyl)-β-cyclodextrin under aqueous conditions that does not require large amounts of polar organic solvents such as DMF, metal-containing reagents such as dibutyltin oxide, or flammable bases such as NaH. Yields are typically around 20%.

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The response factor of the RI detector for both compounds was determined independently and is close to 1.