Catalyst-Free Highly Regio- and Stereoselective Ring Opening of Epoxides and Aziridines with Sodium Azide Using Poly(ethylene glycol) as an Efficient Reaction Medium [1]

Abstract

Ring opening of epoxides and aziridines has readily been carried out at room temperature using poly(ethylene glycol) (PEG-400) as the efficient reaction medium to form the corresponding 2-azido alcohols and 2-azido amines, respectively, in excellent yields (95-99%) within 30-45 minutes and with high regio- and streoselectivity.

Key words

epoxide - aziridine - PEG-400 - 2-azido alcohol - 2-azido amine

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Part 103 in the series ‘Studies on Novel Synthetic Methodologies’; IICT Communication no. 061206.

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Part 103 in the series ‘Studies on Novel Synthetic Methodologies’; IICT Communication no. 061206.