Syntheses of 2-Pyrones via Electrophilic Substitutions at C7 of 4-Hydroxy-6-methyl-2-pyrone through Mono- or Dianion Formation

Xuejun Zhang; Michael McLaughlin; R. Lizeth P. Muñoz; Richard P. Hsung; Jiashi Wang; Jacob Swidorski

doi:10.1055/s-2007-965925

PAPER

Syntheses of 2-Pyrones via Electrophilic Substitutions at C7 of 4-Hydroxy-6-methyl-2-pyrone through Mono- or Dianion Formation

Xuejun Zhang, Michael McLaughlin, R. Lizeth P. Muñoz, Richard P. Hsung*, Jiashi Wang, Jacob Swidorski
Division of Pharmaceutical Sciences and Department of Chemistry, University of Wisconsin, Rennebohm Hall, 777 Highland Avenue, Madison, WI 53705, USA
Fax: +1(608)2625345; e-Mail: rhsung@wisc.edu;

Abstract

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Abstract

Electrophilic substitution protocols useful for functionalizations at C7 of 4-hydroxy-6-methyl-2-pyrone, or triacetic acid, are described here. This method was applied to the synthesis of annularin E.

Key words

dianion - 2-pyrones - 4-hydroxy-6-methyl-2-pyrone - triacetic acid - electrophilic substitution

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Referenzen

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