Synthesis of Pyrrolo[2,1-a]isoquinolines by a Tandem 1,5-Electrocyclisation-Oxidation Process

Judit Tóth; Andrea Nedves; András Dancsó; Gábor Blaskó; László Tőke; Miklós Nyerges

doi:10.1055/s-2007-965959

PAPER

Synthesis of Pyrrolo[2,1-a]isoquinolines by a Tandem 1,5-Electrocyclisation-Oxidation Process

Judit Tóth^a, Andrea Nedves^a, András Dancsó^b, Gábor Blaskó^b, László Tőke^a, Miklós Nyerges*^a
^a Research Group of the Hungarian Academy of Sciences, Department of Organic Chemical Technology, Technical University of Budapest, P.O.B. 91, Budapest 1521, Hungary
Fax: +361(463)3648; e-Mail: mnyerges@mail.bme.hu;
^b EGIS Pharmaceuticals Ltd., P.O.B. 100, Budapest 1475, Hungary

Abstract

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Abstract

A simple protocol for the convenient synthesis of 5,6-dihydropyrrolo[2,1-a]isoquinolines, utilising a one-pot, sequential azomethine ylide 1,5-electrocyclisation-oxidation process is described.

Key words

alkaloids - azomethine ylides - electrocyclic reaction - cycloaddition - pyrroles

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References

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