An adaptation of the Fujioka method for the efficient synthesis of arylimidazolines
from aryl aldehydes was used for the synthesis of aryltetrahydropyrimidines. tert-Butoxycarbonyl-protected bromo- or iodophenyl-substituted imidazolines and tetrahydropyrimidines
both undergo Suzuki coupling reactions with arylboronic acids in good yields.
imidazolines - tetrahydropyrimidines - protecting groups - Suzuki coupling - amidine
heterocycles