New Synthons for the Preparation of Arylimidazolines and Tetrahydro­pyrimidine Analogues

Abstract

An adaptation of the Fujioka method for the efficient synthesis of arylimidazolines from aryl aldehydes was used for the synthesis of aryltetrahydropyrimidines. tert-Butoxycarbonyl-protected bromo- or iodophenyl-substituted imidazolines and tetrahydropyrimidines both undergo Suzuki coupling reactions with arylboronic acids in good yields.

imidazolines - tetrahydropyrimidines - protecting groups - Suzuki coupling - amidine heterocycles

References

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