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Synfacts 2007(6): 0581-0581  
DOI: 10.1055/s-2007-968580
Synthesis of Heterocycles
© Georg Thieme Verlag Stuttgart · New York

One-Pot Cu-Catalyzed Synthesis of 3-Substituted Indazoles

Contributor(s): Victor Snieckus, Yigang Zhao
D. Viña, E. del Olmo*, J. L. López-Pérez, A. San Feliciano
CIETUS, Salamanca, Spain
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Publikationsdatum:
22. Mai 2007 (online)

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Significance

A straightforward method for the synthesis of substituted indazoles and related hetero­cycles (Y = N) by a Cu-catalyzed coupling of 2-haloaryl ketones or 2-halobenzoic acids with hydrazines is described. 2-Haloaryl ketones give better yields than 2-halobenzoic acids which proceed poorly (16-26%). The functional group tolerance and scope of substrates were not well investigated.