PDF icon PDF herunterladen
Synfacts 2007(7): 0675-0675  
DOI: 10.1055/s-2007-968597
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Thiolactomycin

Contributor(s): Philip Kocienski, Fiona Black
K. L. Dormann, R. Brückner*
Universität Freiburg, Germany
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
22. Juni 2007 (online)

   Lizenzen und Reprints
Preview

Significance

Thiolactomycin is a thiotetronic acid antibiotic produced by a Nocardia actinomycete. A synthesis of thiolactomycin and analogues is reported which features an anti-selective SN2′ reaction of a vinyl epoxide with a thiocarboxy­late nucleophile.