Plants as Sources of Antimalarial Drugs. Part 31 Eurycoma longifolia

Kit L. Chan; Melanie J. O'Neill; J. David Phillipson; David C. Warhurst

doi:10.1055/s-2007-969091

Planta Medica, Inhaltsverzeichnis

Planta Med 1986; 52(2): 105-107
DOI: 10.1055/s-2007-969091

Full Papers

Plants as Sources of Antimalarial Drugs. Part 3¹ Eurycoma longifolia

Kit L. Chan³ , Melanie J. O'Neill² , J. David Phillipson² , David C. Warhurst⁴

²Department of Pharmacognosy, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX
³The School of Pharmaceutical Sciences, University of Sains Malaysia, Minden, Penang, Malaysia
⁴Department of Medical Protozoology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1

1 For parts 1 and 2 see references (5) and (6).

Abstract

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Abstract

Extracts of Eurycoma longifolia Jack (Simaroubaceae) have been tested for antiplasmodial activity against a multi-drug resistant Thailand strain (K-1) of Plasmodium falciparum in vitro. 10-Hydroxycanthin-6-one, eurycomalactone, eurycomanone and eurycomanol were isolated form the plant. The in vitro antimalarial activities of these compounds are reported together with that of 6-hydroxy-5, 6-dehydroeurycomalactone.

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