Pharmacological Activity of Prunus spinosa on Isolated Tissue Preparations

R. Rodriguez; B. Lasheras; E. Cenarruzabeitia

doi:10.1055/s-2007-969145

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Planta Med 1986; 52(4): 256-259
DOI: 10.1055/s-2007-969145

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Pharmacological Activity of Prunus spinosa on Isolated Tissue Preparations

R. Rodriguez, B. Lasheras, E. Cenarruzabeitia

Departamento de Fisiología Animal y Farmacología, Facultad de Farmacia, Universidad de Navarra, Pamplona-Navara, Spain.

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Publication History

1985

Publication Date:
26 February 2007 (online)

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Abstract

The pharmacological action of the aqueous extract of Prunus spinosa L. branches has been studied in tissue preparation in vitro. The influence of the extract on rat vas deferens and duodenum was tested using norepinephrine and acetylcholine on spasmogens as well as on guinea pig ileum and taenia coli using histamine and calcium chloride, respectively. The extract reduced responses to norepinephrine, epinephrine and histamine. Responses to cumulative increased Ca²⁺ concentrations in depolarizing bathing medium were also blocked. The P. spinosa L. extract had effects per se on rat vas deferens and guinea pig ileum.