Effects of Sebastiana schottiana Extracts on Isolated Smooth Muscle Contraction

João B. Calixto; Rosendo A. Yunes; Obdulio G. Miguel; Giles A. Rae

doi:10.1055/s-2007-969249

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Planta Med 1986; 52(6): 444-445
DOI: 10.1055/s-2007-969249

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Effects of Sebastiana schottiana Extracts on Isolated Smooth Muscle Contraction

João B. Calixto¹ , Rosendo A. Yunes² , Obdulio G. Miguel² , Giles A. Rae¹

¹Department of Pharmacology-CCB, Universidade Federal de Santa Catarina, 88000 Florianópolis, SC, Brazil.
²Department of Chemistry-CFM, Universidade Federal de Santa Catarina, 88000 Florianópolis, SC, Brazil.

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Publication History

1985

Publication Date:
26 February 2007 (online)

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Abstract

Crude aqueous-ethanol, chloroform, and semipurified flavonoid-glycoside extracts of Sebastiana schottiana (Euphorbiaceae) inhibited contractions of rat uterus to acetylcholine or oxytocin and guinea pig ileum to electric field stimulation. The greatest antispasmodic potency was observed with the chloroform extract. The popular use of this plant in Southern Brazil as a remedy for kidney or bladder calculi may be related to the presence of smooth muscle relaxing compounds.