Cytotoxic Activity of Polyindoline Alkaloids of Psychotria forsteriana (Rubiaceae) (1)

A. Roth; B. Kuballa; C. Bounthanh; P. Cabalion; T. Sévenet; J. P. Beck; R. Anton

doi:10.1055/s-2007-969251

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Planta Med 1986; 52(6): 450-453
DOI: 10.1055/s-2007-969251

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Cytotoxic Activity of Polyindoline Alkaloids of Psychotria forsteriana (Rubiaceae) (1)

A. Roth¹ , B. Kuballa¹ , C. Bounthanh¹ , P. Cabalion² , T. Sévenet³ , J. P. Beck⁴ , R. Anton¹

¹Laboratoire de Pharmacognosie, Faculté de Pharmacie, Université Louis Pasteur, B. P. 10, F-67048 Strasbourg Cedex, France.
²O.R.S.T.O.M., Noumea, New-Hebrides.
³C.N.R.S., Institut de Chimie des Substances Naturelles, F-91190 Gif-sur-Yvette, France.
⁴Laboratoire de Physiologie Générale, Institut de Physiologie, Université Louis Pasteur, 21 Rue Descartes, F-67000 Strasbourg, France.

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Publication History

1986

Publication Date:
26 February 2007 (online)

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Abstract

We have shown that the planar formula of the polyindoline alkaloids (C, B, E and D) isolated from the leaves of Psychotria forsteriana agree respectively with Quadrigemine A, Quadrigemine B, Psychotridine, and Isopsychotridine C. Their cytotoxic activity on cultured rat hepatoma cells (HTC line) is reported in this paper. These alkaloids showed a higher toxicity on HTC cells than vincristine, a bisindole alkaloid currently used in antitumor chemotherapy.

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