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Planta Med 1986; 52(6): 482-483
DOI: 10.1055/s-2007-969259
Communications

© Georg Thieme Verlag Stuttgart · New York

Effects of Various Soyasaponins on Liver Tyrosine Aminotransferase Activity Induced by Cortisone in Adrenalectomized Rats

Yoshiyuki Kimura1 , Hiromichi Okuda1 , Mitsuyoshi Hashimoto1 , Shigeru Arichi2
  • 12nd Department of Medical Biochemistry, School of Medicine, Ehime University, Shigenobu-cho, Onsen-gun, Ehime 791-02, Japan.
  • 2The Research Institute of Oriental Medicine, Kinki University, Sayama-cho, Minamikawachi-gun, Osaka 589, Japan.
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1986

Publikationsdatum:
26. Februar 2007 (online)

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Abstract

It is well known that liver tyrosine aminotransferase activity is induced by administration of steroids to adrenalectomized rats. When various soyasaponins (e.g. soyasaponins I, II, III, A1 and A2) were injected intraperitoneally into adrenalectomized rats, liver tyrosine aminotransferase activity was not found to be induced. Administration of a low dose of cortisone (2.5 mg/kg body weight) to adrenalectomized rats also failed to induce liver tyrosine aminotransferase. However, this enzyme was found to be induced by administration of this low dose of cortisone with soyasaponins II (2.5 mg/kg and 5.0 mg/kg) and A2 (5.0 mg/kg).