Effect of Chinese Herbal Medicine “Saiko-Keishi-To” on Transmembrane Ionic Current of Snail Neurons

Aiko Sugaya; Tadashi Tsuda; Kazumi Yasuda; Eiichi Sugaya

doi:10.1055/s-2007-969394

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Planta Med 1985; 51(1): 60-61
DOI: 10.1055/s-2007-969394

Reports

Effect of Chinese Herbal Medicine “Saiko-Keishi-To” on Transmembrane Ionic Current of Snail Neurons

Aiko Sugaya¹ , Tadashi Tsuda¹ , Kazumi Yasuda¹ , Eiichi Sugaya²

¹Faculty of Pharmaceutical Sciences, Josai University Keyakidai, Sakado-shi, Saitama-ken, Japan
²Department of Physiology, Kanagawa Dental College, Yokosuka, Japan

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Publication History

1984

1984

Publication Date:
26 February 2007 (online)

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Abstract

The effect of the Chinese herbal medicine “Saiko-Keishi-To” (SK) on transmembrane ionic current was examined to elucidate the mechanism of the anticonvulsant action of SK. SK caused a decrease in tramsmembarane sodium, calcium and potassium current. SK was also found to inhibit the negative resistance characteristics in an experiment using a voltage clamp with triangular command.