Untersuchung einiger Pyrrolizidinalkaloide auf chromosomenschädigende Wirkung in menschlichen Lymphocyten in vitro

Abstract

The pyrrolizidine alkaloids senkirkine and tussilagine which occur in the aerial parts of the medicinal plant Tussilago farfara were investigated for their ability to induce chromosome damage in human lymphocytes in vitro. Up to concentrations of 1000 µM the two alkaloids did not enhance the number of structural chromosome aberrations. In contrast, heliotrine, a pyrrolizidine alkaloid used for comparison, induced chromosomal aberrations when tested at a concentration of 100 µM. Additionally, heliotrine was capable to damage the chromosomes of unstimulated lymphocytes, i. e. G₀-phase lymphocytes.