Planta Med 1985; 51(4): 331-334
DOI: 10.1055/s-2007-969504
Research Articles

© Georg Thieme Verlag Stuttgart · New York

Mechanism of Antihepatotoxic Activity of Wuweizisu C and Gomisin A[1]

Yoshinobu Kiso2 , Masahiro Tohkin2 , Hiroshi Hikino2 , Yukinobu Ikeya3 , Heihachiro Taguchi3
  • 2Pharmaceutical Institute, Tohoku University, Aoba-yama, Sendai, Japan
  • 3Tsumura Laboratory, Komae, Tokyo, Japan
Further Information

Publication History

1985

1985

Publication Date:
26 February 2007 (online)

Abstract

The mechanism of inhibitory action of wuweizisu C and gomisin A in carbon tetrachloride (CCl4)-induced liver damage was investigated by determining the effects of these substances on the steps of the series of events leading to liver lesion.

Although wuweizisu C and gomisin A exerted no inhibition in CCl3 radical formation, both lignans inhibited CCl4-, ADP/Fe3+- and ascorbate/Fe2+-induced lipid peroxidation, and wuweizisu C elicited stronger effects than gomisin A which is parallel with the results on antihepatotoxic effects in CCl4-induced cytotoxicity, indicating that anti-oxidative action plays an important part in the antihepatotoxic activity of wuweizisu C and gomisin A.

1 Part 28 in the Tohoku University series on Liver-protective drugs. Also Part 97 on the validity of the Oriental medicines

1 Part 28 in the Tohoku University series on Liver-protective drugs. Also Part 97 on the validity of the Oriental medicines