Plants as Sources of Antimalarial Drugs Part. 1. In vitro Test Method for the Evaluation of Crude Extracts from Plants

M. J. O'Neill; D. H. Bray; P. Boardman; J. D. Phillipson; D. C. Warhurst

doi:10.1055/s-2007-969529

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Planta Med 1985; 51(5): 394-398
DOI: 10.1055/s-2007-969529

Research Articles

Plants as Sources of Antimalarial Drugs Part. 1. In vitro Test Method for the Evaluation of Crude Extracts from Plants

M. J. O'Neill¹ , D. H. Bray¹ , P. Boardman¹ , J. D. Phillipson¹ , D. C. Warhurst²

¹Department of Pharmacognosy, The School of Pharmacy, University of London, 29-39 Brunswick Square, London, WC1N 1AX
²Department of Medical Protozoology, London School of Hygiene and Tropical Medicine, Gower Street, London WC1

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Publication History

1985

1985

Publication Date:
26 February 2007 (online)

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Abstract

An in vitro antimalarial test, utilising the inhibition of uptake of [G-³H]-hypoxanthine into Plasmodium falciparum cultured in human blood, has been used to assess the activity of crude extracts of Artemisia annua and A. vulgaris (Compositae) and of Brucea javanica, Ailanthus altissima, and Simaba cedron (Simaroubaceae).

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