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Planta Med 1985; 51(5): 401-403
DOI: 10.1055/s-2007-969531
Research Articles

© Georg Thieme Verlag Stuttgart · New York

Effects of Saikosaponins on Liver Tyrosine Aminotransferase Activity induced by Cortisone in Adrenalectomized Rats

Mitsuyoshi Hashimoto1 , Kayoko Inada1 , Hiroji Ohminami1 , Yoshiyuki Kimura1 , Hiromichi Okuda1 , Shigeru Arichi2
  • 12nd Department of Medical Biochemistry, School of Medicine, Ehime University, Shigenobu-cho, Onsen-gun, 791-02 Japan.
  • 2The Research Institute of Oriental Medicine, Kinki University, Sayama-cho, Minamikawachi-gun, Osaka, 589 Japan.
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Publication History

1985

1985

Publication Date:
26 February 2007 (online)

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Abstract

Liver tyrosine aminotransferase activity is known to be induced by administration of steroids to adrenalectomized rats. When saikosaponin a, b1, b2, b3, b4, c, d or f was injected intraperitoneally into adrenalectomized rats, no induction of liver tyrosine aminotransferase activity was observed. Administration of a low dose of cortisone (6.4 µmol/kg) to adrenalectomized rats also did not induce liver tyrosine aminotransferase. But this enzyme was induced on administration of this low dose of cortisone with saikosaponen a (6.4 or 12.8 µmol/kg), d (6.4 or 12.8 µmol/kg) or f (12.8 µmol/kg). The sturcture-activity relationship of the effects of various Saikosaponins on the action of cortisone is discuused.