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Planta Med 1985; 51(5): 424-427
DOI: 10.1055/s-2007-969538
Research Articles

© Georg Thieme Verlag Stuttgart · New York

Hypotensive Action of 3α-Dihydrocadambine, An Indole Alkaloid Glycoside of Uncaria Hooks [1]

Kazuo Aisaka[1] , Yoshikazu Hattori2 , Tetsuro Kihara2 , Takafumi Ishihara2 , Katsuya Endo3 , Hiroshi Hikino3
  • 2Suntory Institute for Biomedical Research, 1-1-1, Wakayamadai, Shimamoto-Cho, Mishima-Gun, Osaka 618, Japan
  • 3Pharmaceutical Institute, Tohoku University, Aoba-yama, Sendai, Japan
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Publication History

1985

1985

Publication Date:
26 February 2007 (online)

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Abstract

3α-Dihydrocadambine exhibited dose-dependent hypotensive and anti-hypertensive effects in anesthetized normotensive rats and in conscious spontaneously hypertensive rats. Its activity was much stronger and longer-lasting than that of rhynchophylline. In anesthetized dogs, it caused dilation of the vertebral, femoral and common carotid arteries, and had almost no effect on the coronary artery, whereas it had almost no significant activity in isolated canine arterial strip preparations.

1 Part 90 on the validity of the Oriental medicines

1 Part 90 on the validity of the Oriental medicines