Effect of Hypolaetin-8-Glucoside on Human Platelet Aggregation induced by ADP

A. Villar; M. A. Gascó; M. J. Alcaraz

doi:10.1055/s-2007-969550

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Planta Med 1985; 51(5): 455-456
DOI: 10.1055/s-2007-969550

Reports

Effect of Hypolaetin-8-Glucoside on Human Platelet Aggregation induced by ADP

A. Villar, M. A. Gascó, M. J. Alcaraz

Department of Pharmacognosy and Pharmacodynamics Faculty of Pharmacy. Av. Blasco Ibáñez 13, 46010 Valencia, Spain

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Publication History

1985

1985

Publication Date:
26 February 2007 (online)

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Abstract

Hypolaetin-8-glucoside, a flavonoid isolated from Sideritis mugronensis possessing anti-inflammatory activity inhibited dose-dependently the human PRP aggregation induced by ADP with a IC₅₀ = 2.4 × 10^-4 M. This action does not seem to be related to cyclo-oxygenase, as this flavonoid is not an inhibitor and even is able to act as a cofactor for this enzyme.