New Cleavage Methods for Cardiac Glycosides having a Doubly Linked Sugar1

Kazutake Shimada; Tomoko Kyuno; Jai Seup Ro; Toshio Nambara; Itsuo Uchida

doi:10.1055/s-2007-969606

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Planta Med 1984; 50(1): 9-11
DOI: 10.1055/s-2007-969606

Research Articles

New Cleavage Methods for Cardiac Glycosides having a Doubly Linked Sugar¹

Kazutake Shimada, Tomoko Kyuno, Jai Seup Ro² , Toshio Nambara³ ^, ⁶ , Itsuo Uchida⁴ ^, ⁵

²On leave from College of Pharmacy, Chung-Buk National University, Cheongju 310, Korea
³Pharmaceutical Institute, Tohoku University, Sendai 980, Japan
⁴Department of Chemistry, University of Virginia, Charlottesville, VA 22901, USA
⁵Fujisawa Pharmaceutical Co. Ltd., Osaka, Japan
⁶Toshio Nambara, Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980, Japan

1 A part of this work has been presented (1-4)

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Publication History

Publication Date:
26 February 2007 (online)

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Abstract

New cleavage methods for cardiac glycosides having a doubly linked sugar are described. Treatment with pyridine, alumina, or phenylhydrazine gave the desired genin in reasonable yield. The reaction products were separated and determined by high-performance liquid chromatography. The mechanism of the cleavage reaction has also been discussed.

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