Antihepatotoxic Actions of Flavonolignans from Silybum marianum Fruits

Hiroshi Hikino; Yoshinobu Kiso; Hildebert Wagner; Manfred Fiebig

doi:10.1055/s-2007-969690

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Planta Med 1984; 50(3): 248-250
DOI: 10.1055/s-2007-969690

Research Articles

Antihepatotoxic Actions of Flavonolignans from Silybum marianum Fruits[1]

Hiroshi Hikino² , Yoshinobu Kiso² , Hildebert Wagner³ , Manfred Fiebig³

²Pharmaceutical Institute, Tohoku University, Aoba-yama, Sendai 980, Japan
³Institut für Pharmazeutische Biologie der Universität München, D-8000 München 2, Karlstr. 29

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Publikationsdatum:
26. Februar 2007 (online)

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Abstract

The antihepatatoxic effects of flavonolignans and related constituents from Silybum marianum were examined using carbon tetrachloride- and galactosamine-induced cytotoxicity in primary cultured rat hepatocytes as model systems. Remarkable inhibitory actions were observed with silandrin, 3-deoxysilychristin, silybin and silymonin in carbon tetrachloride-treated cultures, and silydianin and silymonin were effective in preventing galactosamine-produced cell lesions. Possible structure-activity relationships are discussed.

1 Part 16 in the Tohoku University series on Liver-protective drugs