Planta Med 1982; 44(4): 246-248
DOI: 10.1055/s-2007-971459
Research Articles

© Hippokrates Verlag Stuttgart

Effect of Calophyllolide, a Nonsteroidal Anti-Inflammatory Agent, on Capillary Permeability

R. C. Saxena1 , R. Nath1 , G. Palit1 , S. K. Nigam2 , K. P. Bhargava1
  • 1Department of Pharmacology and Therapeutics King George's Medical College, Lucknow, India
  • 2National Botanical Research Institute, Lucknow, India
Further Information

Publication History



Publication Date:
29 March 2007 (online)


Calophyllolide, a nonsteroidal anti-inflammatory agent, was found to be effective in reducing the increased capillary permeability induced in mice by various chemical mediators involved in the inflammatory process viz. histamine (HA), 5-hydroxytryptamine (5-HT) and bradykinin (BK). Pretreatment with Calophyllolide (p. o.) afforded significant protection against induced increase in capillary permeability by HA (PD50 144.1 mg/kg), 5-HT (PD50 250.0 mg/kg) and BK (PD50 133.5 mg/kg). Clinical studies with Calophyllolide in different inflammatory disorders are warranted, in view of its very similar safety margin to oxyphenbutazone (21.4 mg/kg and 25 mg/kg respectively).