Planta Med 1981; 43(11): 240-244
DOI: 10.1055/s-2007-971503
Research Articles

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Inhibitory Action of some Flavonoids on Enhanced Spontaneous Lipid Peroxidation Following Glutathione Depletion

M. Younes, C.-P. Siegers
  • Institut für Toxikologie der Medizinischen Hochschule Lübeck, Federal Republic of Germany
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30. März 2007 (online)


Depletion of hepatic glutathione in phenobarbital-induced rats by phorone (diisopropylidene acetone) led to an enhancement of spontaneous lipid peroxidation in vitro. Addition of exogenous glutathione, dithiocarb or one of the flavonoids (+)-catechin, (-)-epicatechin, 3-O-methylcatechin, quercetin, taxifolin, rutin, naringin or naringenin led in every case to a dose-dependent inhibition of this peroxidative activity. The concentration values yielding 50% inhibition (I50) varied from 1.0 × 10-6 M for glutathione to 1.9 × 10-5 M for naringenin. Naringin and naringenin, which lack the 3′-OH-group, were the least active inhibitors. The only structural feature of the flavonoids which affects their antioxidative action appears thus to be the 3′,4′-dihydroxy-grouping.