Planta Med 2007; 73(6): 597-599
DOI: 10.1055/s-2007-981521
Natural Product Chemistry
Letter
© Georg Thieme Verlag KG Stuttgart · New York

A Bioactive Polyacetylene Compound Isolated from Centella asiatica

G. Govindan1 , T. G. Sambandan1 , M. Govindan2 , A. Sinskey3 , J. Vanessendelft3 , I. Adenan4 , C. K. Rha1
  • 1Biomaterials Science and Engineering Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA
  • 2Department of Chemistry, Fitchburg State College, Fitchburg, MA, USA
  • 3Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA
  • 4Forest Research Institute Malaysia, Kepong Selangor, D. E., Malaysia
Further Information

Publication History

Received: March 8, 2007 Revised: April 9, 2007

Accepted: April 13, 2007

Publication Date:
22 May 2007 (online)

Abstract

A polyacetylene compound was isolated from the aerial parts of Centella asiatica. The chemical structure of this new compound was identified as methyl 5-[(E)-9-hydroxy-1-(1-hydroxyhexyl)-2-methoxyundeca-3,10-diene-5,7-diynyloxy]pentanoate (cadiyenol). This compound induces apoptosis (63 %) independent of cell cycle regimen in mouse lymphoma cells (P388D1) at 28 μM (IC50 = 24 ± 2 μM) in 24 hours. The compound also reduces nitric oxide production by 70 ± 2 % in lipopolysacharride-activated mouse macrophages at 24 μM with no measurable cytotoxicity.

References

Professor ChoKyun Rha

Biomaterials Science and Engineering Laboratory

Massachusetts Institute of Technology

77 Massachusetts Avenue, Room 56-265

Cambridge

MA 02139

USA

Phone: +1-617-253-3493

Fax: +1-617-253-6358

Email: ckrha@mit.edu